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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9679Generated: October 26, 2026

4-[4-(Trifluoromethyl)phenyl]thiophene-3-carbaldehyde → Phenyl{5-[4-(trifluoromethyl)phenyl]thien-3-yl}methanol

https://huagongshe.com/reaction/9679

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[4-(Trifluoromethyl)phenyl]thiophene-3-carbaldehydeHCID 21986376—
Reactant1-{5-[4-(Trifluoromethyl)phenyl]thien-3-yl}ethanolHCID 21986431—
ReactantHCID 178418255HCID 178418255—
ProductPhenyl{5-[4-(trifluoromethyl)phenyl]thien-3-yl}methanolHCID 21986317—

Reaction Steps

The title compound was prepared using a method analogous to that used for the preparation of 1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol (intermediate 126) using 4-[4-(trifluoromethyl)phenyl]thiophene-3-carbaldehyde (intermediate 125) and phenyl magnesium bromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091237B2
Source datasetuspto-grants-2006_08
ORD IDord-2336788b038b41e689f66b799d3c2b1d
Source noteuspto-grants-2006_08