Piperidine → HCID 22291063, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 67 except that the reaction mixture was heated to 100° C. for 16 hours rather than for 6 days, N-[5-(3,5-difluorobenzamido)-2-methylphenyl]-4-diethylaminomethylbenzamide was reacted with piperidine. There was thus obtained the title compound in 83% yield; NMR Spectrum: (DMSOd6) 0.98 (t, 6H), 1.3-1.7 (m, 8H), 2.2 (s, 3H), 2.4-2.5 (m, 2H), 3.2-3.4 (m, 4H), 6.85-6.95 (m, 1H), 7.0-7.1 (m, 1H), 7.2-7.3 (m, 2H), 7.45 (d, 2H), 7.5-7.6 (m, 1H), 7.8 (m, 1H), 7.9 (d, 2H), 9.8 (s, 1H), 10.13 (broad s, 1H); Mass Spectrum: M+H+ 517.

Provenance & Evidence