Triethylamine → HCID 21912438, compound

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A mixture of 6-(1-ethyl-propoxy)-2-methyl-N4-(2,4,6-trimethyl-phenyl)-pyrimidine-4,5-diamine (182 mg, 0.554 mmol), triethylamine (39 mg, 0.388 mmol) and triphosgene (58 mg, 0.196 mmol) in 6 ml of dry THF was stirred at room temperature for 30 min. The mixture was quenched with water and extracted with chloroform. The organic layer was dried and concentrated to give 177 mg (90%) of the title compound as a white solid, mp 159-160° C. 1H NMR (CDCl3) δ 8.50 (s, 1H), 6.99 (s, 2H), 5.30 (m, 1H), 2.47 (s, 3H), 2.32 (s, 3H), 2.08 (s, 6H), 1.73 (m, 4H), 0.94 (t, 6H) ppm.

Provenance & Evidence