反应详情

温度

130 °C

A mixture of 4-chloro-6-methyl-2-(2,4,6-trimethyl-phenoxy)-nicotinic acid methyl ester and 1-ethyl-propyl-amine in DMSO was heated at 130° C. overnight. The mixture was quenched with water, brine and extracted with ethyl acetate. The organic layer was dried and concentrated to dryness. The residue was purified through silica gel column chromatography to give the title compound. 1H NMR(CDCl3) d 8.26(d, 1H), 6.87(s, 2H), 6.26(s, 1H), 4.11(m, 1H), 3.87(s, 3H), 2.324(m, 1H), 2.30(s, 3H), 2.17s, 3H), 2.08(s, 6H), 1.92(q, 2H), 1.16(t, 3H) ppm.

1. customThe mixture was quenched with water, brine
2. extractionextracted with ethyl acetate
3. customThe organic layer was dried
4. concentrationconcentrated to dryness
5. customThe residue was purified through silica gel column chromatography