HCID 22291309, compound → HCID 21912039, compound

HRID 967999Notes

Reaction equation

HRID 967999 reaction equation
[CH2:1]([CH:3]([NH:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([C:22](O)([CH3:24])[CH3:23])=[CH:17][C:16]=2[CH3:26])[C:8]=1[CH3:27])[CH2:4][CH3:5])[CH3:2]>C1C=CC=CC=1>[CH2:1]([CH:3]([NH:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([C:22]([CH3:24])=[CH2:23])=[CH:17][C:16]=2[CH3:26])[C:8]=1[CH3:27])[CH2:4][CH3:5])[CH3:2]

Participants

3

Reactant 1

HCID 22291309HCID 22291309, compound

Product 1

HCID 21912039HCID 21912039, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The title compound was prepared by reacting of 2-[4-[4-(1-Ethyl-propylamino)-3,6-dimethyl-pyridin-2-yloxy]-3,5-dimethyl-phenyl)-propan-2-ol with Burgess Inner salt (Et3NS(Q)2NCOOMe in benzene at reflux for 30 min. 1H NMR(CDCl3) d 7.17(s, 2H), 6.08(s, 1H), 5.34(s, 1H), 5.02(s, 1H), 3.72(d, 1H), 3.32(m, 1H), 2.12 and 2.15 (two sets of s, 12H), 1.4-1.6(m, 4H), 0.97(t, 6H) ppm.

Workup

  1. temperatureat reflux for 30 min

Sources & evidence

ORD record
ord-de4c7efb12614407b8111e0158fe316f
Source dataset
uspto-grants-2005_10
Patent number
US06956047B1

Reaction notes

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