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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9680Generated: October 26, 2026

1-{5-[4-(Trifluoromethyl)phenyl]thien-3-yl}ethanol → 1-{3-Methyl-5-[4-(trifluoromethyl)phenyl]thien-2-yl}ethanol

https://huagongshe.com/reaction/9680

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-{5-[4-(Trifluoromethyl)phenyl]thien-3-yl}ethanolHCID 21986431—
Reactant3-Methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carbaldehydeHCID 21986550—
ReactantHCID 178418573HCID 178418573—
Product1-{3-Methyl-5-[4-(trifluoromethyl)phenyl]thien-2-yl}ethanolHCID 21986359—

Reaction Steps

The title compound was prepared using a method analogous to that used for the preparation of 1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol (intermediate 126) using 3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carbaldehyde (intermediate 74) and methyl magnesium bromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091237B2
Source datasetuspto-grants-2006_08
ORD IDord-11e7000f7bdf4162a75e44daa17cdd60
Source noteuspto-grants-2006_08