N-Fluorobenzenesulfonimide → HCID 21912186, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [2-(4-bromo-2,6-dimethyl-phenoxy)-3,6-dimethyl-pyridin-4-yl]-(1-ethyl-propyl)-amine in dry THF was added n-butylitium at −78° C. After stirring at −78° C. for 10 min, (PhSO2)2NF was added and the resulting mixture was stirred at −78° C. for 30 min, the dry-ice bath was removed. After stirring for 5 min, the mixture was quenched with brine and extracted with ethyl acetate. The organic layer was separated, dried, and concentrated to dryness. The residue was purified through silica gel chromatography to give the title compound. 1H NMR(CDCl3) d 6.77(s, 1H), 6.73(s, 1H), 6.08(s, 1H), 3.3(m, 1H), 2.12(s, 3H), 2.09(s, 6H), 2.08(s, 3H), 1.4-1.8(m, 4H), 0.97(t, 6H), ppm.

Provenance & Evidence