HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N,N,2-Trimethylaniline | HCID 11869 | — |
| Reactant | 2-Chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid | HCID 24806661 | — |
| Catalyst | Copper | HCID 23978 | — |
| Product | 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinic acid | HCID 24806259 | — |
Reaction Steps
The title compound was prepared by heating 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid and trimethylaniline in the presence of potassium carbonate and copper in DMF. The desired product was isolated by silica gel column chromatography using 5% methanol in chloroform as solvent to give a tan solid, mp. 130-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06956047B1 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-70940a9dab06419bb1d0f36cd76ad076 |
| Source note | uspto-grants-2005_10 |