反应详情

The title compound was prepared by reacting 4-(1-ethyl-propoxy)-6-methyl-N2-(2,4,6-trimethyl-phenyl)-pyridine-2,3-diamine with BrCN in acetonitrile at room temperature overnight. The mixture was quenched with water and adjusted to pH 8.0 with saturated sodium bicarbonate and extracted with ethyl acetate. The organic layer was separated, dried and concentrated to give crude material. The material was purified through silica gel column chromatography to give the title compound as a white solid, mp. 159-161° C. 1H NMR(CDCl3) d 7.05(s,2H), 6.5(s,1H), 4.6(m,1H), 4.3(m,2H), 2.45(s,3H), 2.35(s,3H), 2.0(s,6H), 1.7(m,4H), 1.0(t,6H) ppm.

1. customThe title compound was prepared
2. customat room temperature
3. customovernight
4. customThe mixture was quenched with water
5. extractionextracted with ethyl acetate
6. customThe organic layer was separated
7. customdried
8. concentrationconcentrated
9. customto give crude material
10. customThe material was purified through silica gel column chromatography