Ammonia → HCID 22291565, compound

Participants

Reaction Conditions

Reaction Steps

The title product of Step 3 was dissolved in anhydrous ethanol and then an approximately equal volume of liquid ammonia was added. The resulting mixture was sealed in a pressure vessel and then stirred overnight at 100° C. After cooling, the mixture was concentrated. The residue was taken up in dichloromethane—methanol and chromatographed over silica gel using ethyl acetate as eluent to give the title compound, 890 mg, as an oil which crystallized on standing. Anal. for C19H16N4O3.0.75 H2O (MW 361.87): Calc'd.: C, 63.06;, H, 4.46, N, 15.48. Found: C, 63.24; H, 4.70, N, 14.58.

Provenance & Evidence