HCID 22291947, compound → HCID 22291544, compound

HRID 968140Notes

Reaction equation

HRID 968140 reaction equation
[C:1]([N:4](C)[S:5]([C:8]1[CH:13]=[CH:12][C:11]([N:14]2[C:22]3[C:21]4[CH:23]=[C:24]([NH:27][C:28](=[O:36])[C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=5[Cl:35])[CH:25]=[CH:26][C:20]=4[CH2:19][CH2:18][C:17]=3[C:16]([C:37]([NH2:39])=[O:38])=[N:15]2)=[CH:10][CH:9]=1)(=[O:7])=[O:6])(=O)C>[OH-].[Na+].CCO>[Cl:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[C:28]([NH:27][C:24]1[CH:25]=[CH:26][C:20]2[CH2:19][CH2:18][C:17]3[C:16]([C:37]([NH2:39])=[O:38])=[N:15][N:14]([C:11]4[CH:10]=[CH:9][C:8]([S:5]([NH:4][CH3:1])(=[O:6])=[O:7])=[CH:13][CH:12]=4)[C:22]=3[C:21]=2[CH:23]=1)=[O:36]

Participants

4

Reactant 1

HCID 22291947HCID 22291947, compound

Product 1

HCID 22291544HCID 22291544, compoundYield 53%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solid of 1-(4-{[acetyl(methyl)amino]sulfonyl}phenyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide was dissolved in 0.5 N solution of NaOH in EtOH (3 mL) and stirred at room temperature for 2 h. A suspension was formed. It was filtered and washed to give the desired compound (29 mg, 53%.) IKK-2 resin IC50≦1 μM.

Workup

  1. customA suspension was formed
  2. filtrationIt was filtered
  3. washwashed

Sources & evidence

ORD record
ord-15b3952918f14d2dbbde429d2fda4a2b
Source dataset
uspto-grants-2005_10
Patent number
US06956052B2

Reaction notes

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