Acetone → HCID 22288086, compound

Participants

Reaction Steps

A reaction container was charged with 1-(4-methylphenyl)piperidine (4.0 g, 22.8 mmol) and 10 ml of acetone and the mixture was stirred at ambient temperature. Then, α-bromo-p-xylene (5 g, 27.4 mmol) was added to the reaction solution. The reaction solution was stirred for 3 hours and 20 ml of ethyl acetate was added to the solution. The reaction mixture was further stirred for 30 minutes and subjected to suction filtration to collect a white powder. The resulting powder was dried to obtain 4-methylbenzyl(4-methylphenyl)piperidiniumbromide (6.8 g, yield: 83%).

Provenance & Evidence