HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 178461804, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | (2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol | HCID 11857680 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | HCID 178461804 | HCID 178461804 | 29.7% |
Reaction Steps
A stirred solution of the product of step (a) (1 g) in liquid ammonia (20 ml) was treated portionwise with sodium until a permanent blue colour was obtained. The solution was treated with ammonium chloride to dissipate the blue colour, and allowed to evaporate. The residue was taken up in water, filtered and purified by reverse phase preparative HPLC on Xterra® C8 column, using 0 to 20% acetonitrile in water at 20 ml/min over 2 min to give the subtitled compound (0.22 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06958343B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-d5f34948f1bd451db8558f768d8b36c3 |
| Source note | uspto-grants-2005_10 |