2-Acetamido-4-chloromethylthiazole → N-[4-[[[2-Amino-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-5-yl]thio]methyl]-2-thiazolyl]-acetamide

HRID 968208Notes

Reaction equation

HRID 968208 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([SH:15])=[N:6][C:5]=2[N:16]=1.Cl[CH2:18][C:19]1[N:20]=[C:21]([NH:24][C:25](=[O:27])[CH3:26])[S:22][CH:23]=1>>[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([S:15][CH2:18][C:19]3[N:20]=[C:21]([NH:24][C:25](=[O:27])[CH3:26])[S:22][CH:23]=3)=[N:6][C:5]=2[N:16]=1

Participants

3

Reactant 2

HCID 819632-Acetamido-4-chloromethylthiazoleHCID 178461804HCID 178461804, compound

Product 1

HCID 86759884N-[4-[[[2-Amino-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-5-yl]thio]methyl]-2-thiazolyl]-acetamide

Procedure

The titled compound was prepared from the product of example 4, step (b), and N-[4-(chloromethyl)-2-thiazolyl]-acetamide, using the method of example 4, step (c)

Sources & evidence

ORD record
ord-f90195ab31c84370a6ca431bcb031768
Source dataset
uspto-grants-2005_10
Patent number
US06958343B2

Reaction notes

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