5-Chloro-4-(chloromethyl)-1,2,3-thiadiazole → (2R)-2-[[2-Amino-5-[[(5-chloro-1,2,3-thiadiazol-4-yl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

HRID 968209Notes

Reaction equation

HRID 968209 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([SH:15])=[N:6][C:5]=2[N:16]=1.[Cl:17][C:18]1[S:22][N:21]=[N:20][C:19]=1[CH2:23]Cl>>[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([S:15][CH2:23][C:19]3[N:20]=[N:21][S:22][C:18]=3[Cl:17])=[N:6][C:5]=2[N:16]=1

Participants

3

Reactant 2

HCID 27974905-Chloro-4-(chloromethyl)-1,2,3-thiadiazoleHCID 178461804HCID 178461804, compound

Product 1

HCID 86759885(2R)-2-[[2-Amino-5-[[(5-chloro-1,2,3-thiadiazol-4-yl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

Procedure

The titled compound was prepared from the product of example 4, step (b), and 5-chloro-4-(chloromethyl)-1,2,3-thiadiazole, using the method of example 4, step (c).

Sources & evidence

ORD record
ord-2071d77974724d3e92e2cf6d19c103bd
Source dataset
uspto-grants-2005_10
Patent number
US06958343B2

Reaction notes

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