p-Toluenesulfonic acid → HCID 15896315, compound

Participants

Reaction Steps

A solution of the product from example 1, step (d) (0.5 g) in dry toluene (50 ml) containing p-toluene sulphonic acid (25 mg) was heated under reflux for 4 hours. [Analysis of the reaction mixture by 1 c/ms indicated cyclisation was complete but with loss of the acid labile dimethoxybenzyl adduct.] The reaction mixture was evaporated to dryness and the residue purified by chromatography on silica eluting with ethyl acetate to afford the subtitle compound (0.20 g).

Provenance & Evidence