反应详情

温度

50 °C

The product of example 2, step (a) (2 g) was added to a mixture of glacial acetic acid (50 ml) and concentrated nitric acid (20 ml) and the reaction mixture heated to 50° C. A further 28 g of the product of step (a) was added in portions over 2 hours whilst maintaining the reaction temperature between 50 and 60° C. After stirring the reaction mixture for a further 1 hour at 50° C. it was poured onto crushed ice and the subtitled product isolated by filtration as a yellow solid (12.3 g).

1. temperaturewhilst maintaining the reaction temperature between 50 and 60° C
2. additionwas poured
3. customonto crushed ice