Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Serinol | HCID 68294 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 6-bromo-2-[(2,3-difluorobenzyl)thio]-9H-purin-8-ylcarbamate | HCID 178473456 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178508209 | HCID 178508209 | 27.6% |
Reaction Steps
The product of example 5, step (e) (40 mg) was dissolved in NMP and 2-amino-1,3-propanediol (49.2 mg) and diisopropylethylamine (31 μl) base was added and the solution was heated at 150° C. for 36 hr. The reaction mixture was then evaporated to a residue that was purified by preparative HPLC to yield the titled compound as a pale yellow solid (9.5 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06958344B2 |
|---|
| Source dataset | uspto-grants-2005_10 |
|---|
| ORD ID | ord-683335363d7e4d3d93e517588d3d738e |
|---|
| Source note | uspto-grants-2005_10 |
|---|
