Hydrogen Peroxide → HCID 5329433, compound

Participants

Reaction Steps

To a solution of 4-(2-phenyl-1H-imidazol-1-yl)-N-pyridin-3-ylpyrimidin-2-amine (3-3, 0.17 mmol) in CH2Cl2 (1 mL) was added MeReO3 (1 mg) then 30% H2O2 (0.05 mL) with vigorous stirring at room temperature. After 18 hrours additional MeReO3 (1 mg) and 30% H2O2 (0.05 mL) were added. After 18 hours the mixture was concentrated. Purification by reverse phase HPLC (5-100% CH3CN/H2O+0.1% TFA) gave the title compound as a tan solid after trituration with Et2O. 1H-NMR (500 MHz, d6-DMSO) δ 10.38 (s, 1H), 8.68 (d, J=5.13 Hz, 1H), 8.57 (s, 1H), 7.99 (s, 1H), 7.87 (d, J=5.86 Hz, 1H), 7.55 (m, 6H), 7.27 (bs, 1H), 7.20 (s, 1H), 6.86 (d, J=4.64 Hz, 1H).

Provenance & Evidence