HCID 22288337, compound → HCID 22288236, compound

Participants

Reaction Steps

Reduction of intermediate 21 using, for example, zinc dust in glacial acetic acid then provides 3-amino-1,3-dihydro-1,5-benzodiazepin-2-one 22. This reaction is typically conducted at ambient temperature for about 0.5 to about 6 hours. Alternatively, intermediate 21 can be reduced with hydrogen using a catalyst, such as palladium on carbon, to afford 3-amino-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one 23. Typically, this reaction is conducted at ambient temperature for about 12 to about 48 hours. If desired, compounds 22 and 23 can then be coupled with an amino acid derivative using the procedures described herein.

Provenance & Evidence