Tert-butoxycarbonylalanine → HCID 23552794, compound

HRID 968265Notes

Reaction equation

C([NH:8][C@H:9]([C:11](O)=[O:12])[CH3:10])(OC(C)(C)C)=O.[ClH:14].[NH2:15][N:16]1[C:22](=[O:23])[CH:21]([CH3:24])[C:20]2[CH:25]=[C:26]([F:29])[CH:27]=[CH:28][C:19]=2[C:18]2[CH:30]=[CH:31][CH:32]=[CH:33][C:17]1=2>>[ClH:14].[NH2:8][C@H:9]([C:11]([NH:15][N:16]1[C:22](=[O:23])[CH:21]([CH3:24])[C:20]2[CH:25]=[C:26]([F:29])[CH:27]=[CH:28][C:19]=2[C:18]2[CH:30]=[CH:31][CH:32]=[CH:33][C:17]1=2)=[O:12])[CH3:10]

Participants

Reactant 2

HCID 85082Tert-butoxycarbonylalanine

HCID 22288346HCID 22288346, compound

Product 1

HCID 23552794HCID 23552794, compound

Procedure

Following General Procedure D and using N-Boc-L-alanine (Aldrich) and 5-amino-9-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (Example 12), the title compound was prepared.

Sources & evidence

ORD record: ord-6173dac7d92540639160119d8a72ba73
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06958330B1

Reaction notes

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