反应详情

A solution of 5-ethyl-8-nitro-5H-phenanthridin-6-one I-16b (100 mg, 0.37 mmol) in ethyl alcohol (25 ml) was charged with 10% palladium on activated carbon (25 mg). The resultant suspension was placed on a Parr hydrogenation apparatus and shaken under 50 psi H2 for 3 hours. The catalyst was removed by filtration through celite, and the filtrate was concentrated in vacuo to afford 8-amino-5-ethyl-5H-phenanthridin-6-one I-16c (74 mg, 84%).

1. customThe catalyst was removed by filtration through celite
2. concentrationthe filtrate was concentrated in vacuo