Methyl iodide → HCID 22288830, compound

Participants

Reaction Steps

Intermediate 1 was dissolved in ethanol and treated with 8 equivalents of methyl iodide. The mixture was heated to reflux for 8 h. After it cooled to RT, the reaction solution was filtered through activated carbon and the filtrate was concentrated in vacuo. The residue was treated with 0.5 N HCl and the precipitate was filtered off with suction after 30 min. The residue was stirred once more with EA and dried. The title compound was isolated in a yield of 47%. M.p.: 333-335° C.

Provenance & Evidence