HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloro-2-isothiocyanatobenzene → N-(2-Amino-5-fluorophenyl)-N′-(2,6-dichlorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloro-2-isothiocyanatobenzene | HCID 123239 | — |
| Reactant | 4-Fluorobenzene-1,2-diamine | HCID 164584 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(2-Amino-5-fluorophenyl)-N′-(2,6-dichlorophenyl)thiourea | HCID 22288818 | 77.9% |
Reaction Steps
A mixture of 4.37 g (0.0346 mol) of 4-fluoro-1,2-diaminobenzene and 7.07 g (0.0346 mol) of 2,6-dichlorophenyl isothiocyanate in 150 ml of EA was boiled under reflux for 3 hours. After distilling off the solvent, the residue was dissolved in methanol, treated with activated carbon, ⅔ of the solvent volume was distilled off, and the thiourea was allowed to crystallize in an ice bath for a number of hours. 8.9 g of the desired product was obtained. Colorless crystals, 1st m.p.: 175-178° C.; 2nd m.p.: 294-296° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06958357B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-15d5d38d9dce43be9a46240b30d5f4f8 |
| Source note | uspto-grants-2005_10 |