反应详情

To a toluene (80 mL) solution containing 4-{2-[(6-bromo-2-pyridinyl)oxy]ethoxy}benzaldehyde (1 g) and tetrakis(triphenylphosphine)palladium (0.18 g), a 2M aqueous solution (4 mL) of sodium carbonate and a solution of 2,4-difluorophenylbenzeneboronic acid (0.64 g) in ethanol (4 mL) were added. The resultant mixture was refluxed for four hours. After completion of reaction, the reaction mixture was poured into saturated saline, and the thus-obtained toluene layer of the resultant mixture was separated. The separated layer was dried over magnesium sulfate, and the residual solvent was removed through distillation under reduced pressure. The thus-yielded residue was purified by means of a silica gel column, to thereby yield 0.71 g of the title compound as colorless crystals (yield 64.5%).

1. customAfter completion of reaction
2. additionthe reaction mixture was poured into saturated saline
3. customthe thus-obtained toluene layer of the resultant mixture was separated
4. dry with materialThe separated layer was dried over magnesium sulfate
5. customthe residual solvent was removed through distillation under reduced pressure
6. customThe thus-yielded residue was purified by means of a silica gel column