反应详情

2-chloropyridine (12 g) and 2-(methylamino)ethanol (100 ml) are stirred under nitrogen at 120° C. for 18 hours. Cool to room temperature and then pour into iced water (250 ml). Extract with ethyl acetate (2×200 ml). Dry over sodium sulfate. Filter. Evaporate to dryness. The crude product is distilled in vacuo to give 10.3 g of N-methyl-N-(2-pyridinyl)-2-aminoethanol, boiling at 110° C./1.0 mmHg.

1. extractionExtract with ethyl acetate (2×200 ml)
2. dry with materialDry over sodium sulfate
3. filtrationFilter
4. customEvaporate to dryness
5. distillationThe crude product is distilled in vacuo