Pyridine → HCID 22226274, compound

HRID 968339Notes

Reaction equation

HRID 968339 reaction equation
[Cl-].[Cl:2][CH2:3][C:4]([CH2:6]Cl)=[O:5].C(OCC)C.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Cl-:2].[Cl:2][CH2:3][C:4](=[O:5])[CH2:6][N+:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 3283Diethyl EtherHCID 22226299HCID 22226299, compound

Product 1

HCID 22226274HCID 22226274, compound

Procedure

66.9 g of 1,3-dichloroacetone chloride are introduced into a three-necked flask containing 800 cm3 of diethyl ether. 28 cm3 of pyridine are added dropwise and the mixture is kept stirring overnight. The precipitate obtained is filtered, washed with twice 100 cm3 of diethyl ether and then dried at 40° C. under 90 Pa to give 29.2 g of 1-(3-chloro-2-oxopropyl)-pyridinium chloride in the form of a cream-coloured solid melting at 92° C. and which is used as it is.

Workup

  1. customThe precipitate obtained
  2. filtrationis filtered
  3. washwashed with twice 100 cm3 of diethyl ether
  4. customdried at 40° C. under 90 Pa

Sources & evidence

ORD record
ord-ff8bbe6b62d641aea6e151ff4380dc56
Source dataset
uspto-grants-2005_10
Patent number
US06958383B2

Reaction notes

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