HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-nitrophenol → HCID 11367981, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-nitrophenol | HCID 9937 | — |
| Reactant | 2-Methylimidazole | HCID 12749 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 11367981 | HCID 11367981 | 78% |
Reaction Steps
A solution of 5-fluoro-2-nitrophenol (2.03 g) and 2-methylimidazole (2.14 g) in CH3CN (50 mL) was stirred at reflux under N2 for 16 h. The solvent was removed and the residue was purified by chromatography on silica gel with 0-10% MeOH in CH2Cl2 to give 2.21 g of 5-(2′-methylimdazol-1-yl)-2-nitrophenol. ESI mass spectrum z (rel. intensity) 220.1 (M+H, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06958356B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-d4516274a70342708c187a76d7cf95d9 |
| Source note | uspto-grants-2005_10 |