3,5-Dibromopyridine → 3-Bromo-5-methoxypyridine

Temperature

150 °C

A mixture of 3,5-dibromopyridine (20.00 g, 84.42 mmol), sodium methoxide (11.40 g, 211.06 mmol), and copper powder (1 g, 5% by weight of 3,5-dibromopyridine) in dry methanol was heated in a sealed glass tube at 150° C. for 14 h. The reaction mixture was cooled to ambient temperature and extracted with diethyl ether (4×200 mL). The combined ether extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation. The crude product was purified by column chromatography over aluminum oxide, eluting with ethyl acetate-hexane (1:9, v/v). Selected fractions were combined and concentrated by rotary evaporation, producing 9.40 g (59.5%) of a colorless oil, which tended to crystallize upon cooling.

1. temperatureThe reaction mixture was cooled to ambient temperature
2. extractionextracted with diethyl ether (4×200 mL)
3. dry with materialThe combined ether extracts were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated by rotary evaporation
6. customThe crude product was purified by column chromatography over aluminum oxide
7. washeluting with ethyl acetate-hexane (1:9, v/v)
8. concentrationconcentrated by rotary evaporation

ORD record

ord-1af15c8d2e224ab9a7edbcfb698d97a6

Source dataset

uspto-grants-2005_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06958399B2