Water → HCID 135422991, compound

HRID 968454Notes

Reaction equation

HRID 968454 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[OH2:23]>>[OH2:23].[OH2:23].[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 962WaterHCID 135398745Olanzapine

Product 1

HCID 135422991HCID 135422991, compound

Conditions

Temperature
25 °C

Procedure

A 10 g sample of technical grade olanzapine was suspended in water (88 mL). The mixture was stirred at about 25° C. for 6 hours. The product was isolated using vacuum filtration. The product was identified as Dihydrate B olanzapine using x-ray powder analysis. Yield: 10.86 g.

Workup

  1. customThe product was isolated
  2. filtrationvacuum filtration

Sources & evidence

ORD record
ord-86f009d15ebb4bd1968317a68ff192ea
Source dataset
uspto-grants-2007_12
Patent number
US07303764B2

Reaction notes

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