反应详情

3-Nitrophenylsulphonyl chloride was added at 0° C. to a solution of 11.6 g ethyl 3-{[(allyloxy)-carbonyl]-amino}-3-(3-aminophenyl)-propanoate from Example II.2.d in 110 ml of pyridine. After a reaction time of 2 h, the mixture was concentrated, 1 N hydrochloric acid was added, and the solution was extracted with dichloromethane. After drying the organic phase over magnesium sulphate, the solvent was removed and the crude product was purified by chromatography on silica gel (dichloromethane/methanol=40:1) to give 17.8 g of a solid.

1. concentrationAfter a reaction time of 2 h, the mixture was concentrated
2. addition1 N hydrochloric acid was added
3. extractionthe solution was extracted with dichloromethane
4. dry with materialAfter drying the organic phase over magnesium sulphate
5. customthe solvent was removed
6. customthe crude product was purified by chromatography on silica gel (dichloromethane/methanol=40:1)