反应详情

43.5 g of tin-(II) chloride were added to a solution of 17.8 g of ethyl 3-{[(allyloxy)-carbonyl]-amino}-3-{{3-{[(3-nitrophenyl)-sulfonyl]-amino}-phenyl}}-propanoate from Example II.2.e in 165 ml of ethanol, and the mixture was heated to reflux for a period of time of 2 h. The reaction mixture was hydrolized with 200 ml of aqueous 2N sodium hydroxide solution, then filtered through silica gel and washed with dichloromethane. The organic phase was dried over magnesium sulphate and concentrated to yield 9.2 g of a solid.

1. temperaturethe mixture was heated
2. temperatureto reflux for a period of time of 2 h
3. filtrationfiltered through silica gel
4. washwashed with dichloromethane
5. dry with materialThe organic phase was dried over magnesium sulphate
6. concentrationconcentrated