反应详情

温度

50 °C

9.6 g of propyl isocyanate were added to a solution of 50 g of enantiopure ethyl 3-{[(allyloxy)-carbonyl]-amino}-3-{{3-{[(3-aminophenyl)-sulfonyl]-amino}-phenyl}}-propanoate from fraction 1 from Example II.2.f in 500 ml of dioxane, and the mixture was stirred for 18 h at 50° C. After evaporation of the solvent, 1.5 L of 1 M hydrochloric acid were added, and the solution was extracted with dichloromethane. The organic phase was dried over magnesium sulphate and concentrated. Chromatography on silica gel (dichloromethane/methanol=30:1) yielded 19.1 g of the compound.

1. customAfter evaporation of the solvent, 1.5 L of 1 M hydrochloric acid
2. additionwere added
3. extractionthe solution was extracted with dichloromethane
4. dry with materialThe organic phase was dried over magnesium sulphate
5. concentrationconcentrated