1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Participants

Reaction Steps

The title compound was prepared in a procedure analogous to that used in Example 6, using N-[2-Oxo-3-(2,3,4,5-tetrahydro-1 H-benzo[d]azepin-7-yl)-oxazolidin-5-ylmethyl]-acetamide (0.25 g) and 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (0.23 g). The product was triturated with EtOH to purify. MS (APCI) AP+, 567. NMR (DMSO6)1. 1-1.22 (m, 4H), 1.78 (s, 3H), 3.0 (m, 4H), 3.35 (m, 6H), 3.65 (m, 1H), 4.05 (m, 2H), 4.65 (m, 1H), 7.13 (d, 1H), 7.26 (dd, 1H), 7.35 (d, 1H), 7.78 (d, 1H), 8.17 (t, 1H), 8.62 (s, 1H).

Provenance & Evidence