HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 968487Generated: October 27, 2026
Water → 8-[2-(4-Methoxyphenyl)ethyl]-1,4-dioxa-8-azaspiro[4.6]undecane
https://huagongshe.com/reaction/968487
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-Bromoethyl)-4-methoxybenzene | HCID 84427 | — |
| Reactant | 1,4-Dioxa-8-azaspiro[4.6]undecane | HCID 21679591 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-[2-(4-Methoxyphenyl)ethyl]-1,4-dioxa-8-azaspiro[4.6]undecane | HCID 69282949 | 85.8% |
Reaction Steps
A mixture of intermediate (5) (0.114 mol), 1-(2-bromoethyl)-4-methoxy-benzene (0.172 mol) and K2CO3 (0.219 mol) in ACN (200 ml) was stirred at 80° C. for 2 hours. Water was added and the mixture was extracted with DCM. The organic layer was separated, dried , filtered and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH/NH4OH 95/5/0.2). The pure fractions were collected and the solvent was evaporated, yielding 28.5 g of 8-[2-(4-methoxyphenyl)ethyl]-1,4-dioxa-8-azaspiro[4.6]undecane (intermediate 6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07304052B2 |
|---|
| Source dataset | uspto-grants-2007_12 |
|---|
| ORD ID | ord-0177bc7bb4844c0abf2d812eb1e53609 |
|---|
| Source note | uspto-grants-2007_12 |
|---|
