HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R)-thiomorpholine-3-carboxylic acid methyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (3R)-thiomorpholine-3-carboxylic acid methyl ester | HCID 12858836 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (3R)-thiomorpholine-3-carboxylic acid methyl ester hydrochloride | HCID 12858835 | 97.2% |
Reaction Steps
10.9 g of (3R)-thiomorpholine-3-carboxylic acid methyl ester was dissolved in 150 mL of ether and 90 mL 14.5% of hydrogen chloride dissolved in ethanol was added dropwise in the above solution to obtain 13.0 g of (3R)-thiomorpholine-3-carboxylic acid methyl ester hydrochloride as a white solid. Yield 97.2%□mp 160-161° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304057B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-43df5b0db3a84be49789c6be86763655 |
| Source note | uspto-grants-2007_12 |