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Hydrogen Bromide → 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | [2-Methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea | HCID 22015747 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine | HCID 22015735 | — |
反応手順
To a solution of 1 [2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea (XI) in acetic acid is added hydrobromic acid, and stirring continued for about 30 min at 80° C. DMSO is then added dropwise and the reaction mixture stirred for a further 30 min at 80° C. The product (XII) 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine is isolated by conventional means.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07304058B2 |
| 出典データセット | uspto-grants-2007_12 |
| ORD ID | ord-58071eab15a4470e83f4aaa19074f653 |
| 出典メモ | uspto-grants-2007_12 |