4-(Trifluoromethyl)phenylboronic acid → HCID 44410502, compound

HRID 968553Notes

Reaction equation

HRID 968553 reaction equation
COC1C=CC([C:9]2[CH:10]=[N:11][CH:12]=[C:13]([CH2:15][N:16]3[CH2:22][CH2:21][CH2:20][CH2:19][C@H:18]([NH:23][C:24](=[O:37])[C@H:25]([CH2:33][CH:34]([CH3:36])[CH3:35])[C@H:26]([CH2:30][CH2:31][CH3:32])[C:27]([NH2:29])=[O:28])[C:17]3=[O:38])[CH:14]=2)=CC=1.[F:39][C:40]([F:51])([F:50])[C:41]1[CH:46]=[CH:45][C:44](B(O)O)=[CH:43][CH:42]=1>>[F:39][C:40]([F:51])([F:50])[C:41]1[CH:46]=[CH:45][C:44]([C:9]2[CH:10]=[N:11][CH:12]=[C:13]([CH2:15][N:16]3[CH2:22][CH2:21][CH2:20][CH2:19][C@H:18]([NH:23][C:24](=[O:37])[C@H:25]([CH2:33][CH:34]([CH3:35])[CH3:36])[C@H:26]([CH2:30][CH2:31][CH3:32])[C:27]([NH2:29])=[O:28])[C:17]3=[O:38])[CH:14]=2)=[CH:43][CH:42]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 44410499HCID 44410499, compound

Product 1

HCID 44410502HCID 44410502, compound

Procedure

The general procedure reported for the compound of Example 30 was followed using 4-trifluoromethylphenyl boronic acid. Purification by HPLC afforded 6.0 mg of the desired product from as its trifluoroacetic acid salt. MS (M+Na)+=583.

Workup

  1. customPurification by HPLC

Sources & evidence

ORD record
ord-0ed87261f3194bdca7b411bb782b5584
Source dataset
uspto-grants-2007_12
Patent number
US07304056B2

Reaction notes

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