反应详情

To a solution of 2-amino-4-bromo-benzonitrile (550 mg, 2.79 mmol) in formic acid, add sodium acetate (435 mg, 5.30 mmol) in one portion. Reflux the reaction mixture for 16 h then remove the formic acid under reduced pressure to give a solid. Add 20% aqueous NaOH and stir for 1 hour. Remove the undissolved solids via filtration and acidify the filtrate with 12N HCl to produce a white solid. Collect the solid via filtration and wash it with water (5×) and ether (1×) to give 7-bromo-3H-quinazolin-4-one as an off-white solid.

1. temperatureReflux the reaction mixture for 16 h
2. customthen remove the formic acid under reduced pressure
3. customto give a solid
4. customRemove the undissolved solids
5. filtrationvia filtration
6. customto produce a white solid
7. customCollect the solid
8. filtrationvia filtration
9. washwash it with water (5×) and ether (1×)