HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Amino-4(3-trifluoromethyl-pyridin-2-yl)-benzo-nitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-Nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzonitrile | HCID 22030063 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-Amino-4(3-trifluoromethyl-pyridin-2-yl)-benzo-nitrile | HCID 22030496 | — |
Reaction Steps
To an ice-water cooled solution of 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzonitrile (0.44 mmol) in conc. HCl (6 mL) add SnCl2 (1.457 mmol). Stir the mixture 2 h at room temperature. neutralize with NaOH, extract with EtOAc, dry over Na2SO4, and concentrate under vacuum. Purify the residue by flash chromatography (4:1 hexanes/EtOAc) to give 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzo-nitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304059B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-32b131b615f74886a99b4fcd4c5ae2be |
| Source note | uspto-grants-2007_12 |