HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Amino-4(3-trifluoromethyl-pyridin-2-yl)-benzo-nitrile | HCID 22030496 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide | HCID 22030074 | — |
Reaction Steps
Stir a mixture of 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzo-nitrile (0.50 mmol) in 70% H2SO4 (10 ml) at 110° C. for 1 hour. Cool to room temperature, neutralize with NaOH, extract with EtOAc, dry over Na2SO4, and concentrate under vacuum. Purify the residue by flash chromatography (3:2 hexanes/EtOAc) to give 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304059B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-34008914c3a84f3486a96cb6c190f2d0 |
| Source note | uspto-grants-2007_12 |