4-Tert-Butylaniline → HCID 10216740, compound

HRID 968582Notes

Reaction equation

HRID 968582 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][N:13]=3)=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:22])[N:3]=1.[C:23]([C:27]1[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=1)([CH3:26])([CH3:25])[CH3:24]>>[C:23]([C:27]1[CH:28]=[CH:29][C:30]([NH:31][C:2]2[C:11]3[C:6](=[CH:7][C:8]([C:12]4[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][N:13]=4)=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:22])[N:3]=2)=[CH:32][CH:33]=1)([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 698614-Tert-ButylanilineHCID 22030485HCID 22030485, compound

Product 1

HCID 10216740HCID 10216740, compound

Procedure

Using procedures analogous to those already described, (4-tert-Butyl-phenyl)-[2-methyl-7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-yl]-amine is prepared by condensing 4-chloro-2-methyl-7-(3-trifluoromethyl-pyridin-2-yl)-quinazoline with 4-tert-butylaniline. Mass spec. 436.2.

Sources & evidence

ORD record
ord-ffda88ffa74c42fe9b6d76bd8f6668aa
Source dataset
uspto-grants-2007_12
Patent number
US07304059B2

Reaction notes

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