HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 2-(4-Methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 2-p-Tolyl-3-trifluoromethyl-pyridine | HCID 22030373 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-(4-Methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine | HCID 22030128 | — |
Reaction Steps
To a solution of 2-p-tolyl-3-trifluoromethyl-pyridine (8.4 mmol) in H2SO4 (6 mL) cautiously add fuming HNO3 (2 ml). Stir the mixture 60 minutes at room temperature. Pour the mixture onto ice-water (30 mL), extract with EtOAc, neutralize with 1 N NaOH, dry over Na2SO4, and concentrate under vacuum to obtain 2-(4-methyl-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304059B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-7db3a38e386349e9adc6a534a3a05bb2 |
| Source note | uspto-grants-2007_12 |