Formamide → HCID 178517950, compound

HRID 968586Notes

Reaction equation

HRID 968586 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([C:11]2[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:21]([NH2:23])=O>O>[F:18][C:17]([F:20])([F:19])[C:16]1[C:11]([C:9]2[CH:10]=[C:2]3[C:3]([C:4]([OH:6])=[N:23][CH:21]=[N:1]3)=[CH:7][CH:8]=2)=[N:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 713FormamideHCID 220302532-Amino-4-[3-(trifluoromethyl)-2-pyridinyl]benzoic acid

Product 1

HCID 178517950HCID 178517950, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Stir the mixture of 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid (1.95 mmol) in HCONH2 (10 mL) for 4 hours at 145° C. Cool to room temperature, dilute with 20 ml of water, and collect the precipitate to give 7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ol.

Workup

  1. customcollect the precipitate

Sources & evidence

ORD record
ord-1862e8cb8a8b4dc69ef4933f0ea387e0
Source dataset
uspto-grants-2007_12
Patent number
US07304059B2

Reaction notes

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