HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trimethoxy-2-chloroethane → 2-chloromethyl-7-(3-trifluoromethyl-pyridin-2-yl)-3H-quinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trimethoxy-2-chloroethane | HCID 144702 | — |
| Reactant | 2-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide | HCID 22030074 | — |
| Product | 2-chloromethyl-7-(3-trifluoromethyl-pyridin-2-yl)-3H-quinazolin-4-one | HCID 135682066 | — |
Reaction Steps
Heat a solution of 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (100 mg, 0.356 mmol) in 2-chloro-1,1,1-trimethoxyethane (bp 138° C.) at 130° C. for 4 hours. Concentrate the mixture under reduced pressure to give 2-chloromethyl-7-(3-trifluoromethyl-pyridin-2-yl)-3H-quinazolin-4-one as an oil which crystallizes on standing.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304059B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-1823eccdacc2481ca13e728431c11dd7 |
| Source note | uspto-grants-2007_12 |