Nitric Acid → HCID 22030083, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-trifluoromethyl-1′H-[2,3′]bipyridinyl-6′-one (25 g, 0.1 mol) in concentrated sulfuric acid (100 mL) at 0° C., add dropwise a solution of fuming nitric acid (35 mL) and concentrated sulfuric acid (10 mL). Heat the reaction mixture to 70° C. for 1 hour, cool and pour onto ice (500 mL). Filter the mixture and treat the filtrate with 10 M sodium hydroxide until the solution is at pH 4–5. Collect the precipitate by filtration and air dry to give the title compound (26.2 g, 92%) as a white solid.

Provenance & Evidence