2-(pyrrolidin-1-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-4-amine → [7-(3-Methyl-pyridin-2-yl)-2-pyrrolidin-1-ylmethyl-pyrido[3,2-d]pyrimidin-4-yl]-(4-trifluoromethyl-phenyl)-amine

HRID 968608Notes

Reaction equation

HRID 968608 reaction equation
[NH2:1]C1C(C(N)=O)=NC=C(C2C(C)=CC=CN=2)C=1.[N:18]1([CH2:23][C:24]2[N:33]=[C:32]([NH:34][C:35]3[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][CH:36]=3)[C:31]3[C:26](=[CH:27][C:28]([C:45]4[C:50]([C:51](F)(F)F)=[CH:49][CH:48]=[CH:47][N:46]=4)=[CH:29]C=3)[N:25]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH3:51][C:50]1[C:45]([C:28]2[CH:29]=[N:1][C:31]3[C:32]([NH:34][C:35]4[CH:36]=[CH:37][C:38]([C:41]([F:42])([F:44])[F:43])=[CH:39][CH:40]=4)=[N:33][C:24]([CH2:23][N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)=[N:25][C:26]=3[CH:27]=2)=[N:46][CH:47]=[CH:48][CH:49]=1

Participants

3

Reactant 2

HCID 220302732-(pyrrolidin-1-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-4-amineHCID 220304133-Amino-5-(3-methyl(2-pyridyl))pyridine-2-carboxamide

Product 1

HCID 10195371[7-(3-Methyl-pyridin-2-yl)-2-pyrrolidin-1-ylmethyl-pyrido[3,2-d]pyrimidin-4-yl]-(4-trifluoromethyl-phenyl)-amine

Procedure

The title compound is prepared from 3-amino-5-(3-methyl(2-pyridyl))pyridine-2-carboxamide in a manner analogous to that used for the preparation of [2-pyrrolidin-1-ylmethyl-7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-yl]-(4-trifluoromethyl-phenyl)-amine (Example 2.A, steps 6 to 9).

Sources & evidence

ORD record
ord-910d624f8b7a4ea5b47e58a777878c4b
Source dataset
uspto-grants-2007_12
Patent number
US07304059B2

Reaction notes

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