HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro4-(3-trifluoromethyl-pyridin-2-yl)-benzamide → 2-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro4-(3-trifluoromethyl-pyridin-2-yl)-benzamide | HCID 22030050 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide | HCID 22030074 | — |
Reaction Steps
Hydrogenate 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (1.0 g, 0.0032 mol) with 5.0 psi of H2 and 100 mg of 10% Pd/C in ethanol. After 16 hours, filter the mixture through celite and concentrate under reduced pressure to give 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304059B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-9ba3a06742654fbe89400df8528efd6e |
| Source note | uspto-grants-2007_12 |