HCID 22030186, compound → HCID 22030009, compound

HRID 968618Notes

Reaction equation

HRID 968618 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:5][CH:4]=1>Br.CC(O)=O>[F:17][C:15]([F:16])([F:18])[C:14]1[C:9]([C:6]2[CH:5]=[CH:4][C:3](=[O:2])[NH:8][CH:7]=2)=[N:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 1

HCID 22030186HCID 22030186, compound

Product 1

HCID 22030009HCID 22030009, compoundYield 93.7%

Reagents, catalysts & solvents 1

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidSolvent

Procedure

Heat 6′-Methoxy-3-trifluoromethyl-[2,3′]bipyridinyl (41 g, 0.16 mol) in 30% HBr/AcOH (100 mL) to reflux for 1 hour. Cool the mixture, filter and wash the precipitate with ether (100 mL). Transfer the precipitate into 10M sodium hydroxide (500 mL) and stir for 1 hour. Treat the solution with hydrochloric acid until the solution is pH 7. Collect the white solid by filtration and air dry to give the title compound (36 g, 93%) as a white solid.

Workup

  1. temperatureto reflux for 1 hour
  2. temperatureCool the mixture
  3. filtrationfilter
  4. washwash the precipitate with ether (100 mL)
  5. additionTreat the solution with hydrochloric acid until the solution
  6. customCollect the white solid
  7. filtrationby filtration and air
  8. customdry

Sources & evidence

ORD record
ord-e1147c9a8cf4459c81bf288ebaa2aeeb
Source dataset
uspto-grants-2007_12
Patent number
US07304059B2

Reaction notes

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