2-Fluoroaniline → HCID 86030630, compound

Participants

Reaction Conditions

Reaction Steps

A solution of NaNO2 (0.96 g) in conc. H2SO4 (4 mL) was added to a solution of 2-fluoroaniline (1.52 g) in AcOH (23 mL) at 0° C., and the mixture was stirred for 1 hour at 0° C. The reaction mixture was added to a solution of ethyl 4-chloro-3-oxobutanoate (2.16 g) in a mixture of AcOH (10 mL) and H2O (20 mL) at 0° C. and the reaction mixture was stirred for 15 minutes at 0° C. A solution of NaOAc (12.2 g) in H2O (20 mL) was added to the reaction mixture at 0° C., and the reaction mixture was stirred for 1 hour at room temperature to produce a precipitate. The precipitate was collected by filtration and washed with H2O to yield 2.75 g of the title compound. AcOH and NaOAc means acetic acid and sodium acetate, respectively.

Provenance & Evidence